(+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline

Base Information

Chemical Name:(+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline
CAS No.:1050526-93-6
Molecular Formula:C₂₇H₂₄Cl₃N₃
Molecular Weight:496.867
Hs Code.:

Synonyms:(+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline

Suppliers and Price of (+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline

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Technology Process of (+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline

There total 5 articles about (+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1050527-81-5
(3-chlorophenyl)(3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl)methanamine

: 1050526-93-6
(+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline

Guidance literature:: With pyridine hydrochloride; In 2-ethoxy-ethanol; at 135 ℃; for 5h;
DOI:10.1021/jm300802s

Reference yield: 52.0%

: 1050526-93-6
(+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline

Guidance literature:

Reference yield:

: 587-04-2
m-Chlorobenzaldehyde

: 1050526-93-6
(+/-)-7-chloro-N-{[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl](3-chlorophenyl)methyl}-4-aminoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: iodine; magnesium / tetrahydrofuran / Reflux

1.2: 4 h / 83 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / Reflux

3.1: triethylamine / acetonitrile / 1 h / 0 °C

4.1: hydroxylamine hydrochloride; barium carbonate / methanol / 18 h / Reflux

5.1: acetic acid; zinc / 18 h / 50 °C

6.1: pyridine hydrochloride / 2-ethoxy-ethanol / 5 h / 135 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; iodine; pyridine hydrochloride; magnesium; acetic acid; triethylamine; barium carbonate; zinc; In tetrahydrofuran; methanol; 2-ethoxy-ethanol; tetrachloromethane; acetonitrile;
DOI:10.1021/jm300802s