4-acetyl-3-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]-2-methylene-5-oxohexanoic acid methyl ester

Base Information

Chemical Name:4-acetyl-3-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]-2-methylene-5-oxohexanoic acid methyl ester
CAS No.:884537-21-7
Molecular Formula:C₂₀H₂₀ClNO₅
Molecular Weight:389.835
Hs Code.:

Synonyms:4-acetyl-3-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]-2-methylene-5-oxohexanoic acid methyl ester

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Chemical Property of 4-acetyl-3-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]-2-methylene-5-oxohexanoic acid methyl ester

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Technology Process of 4-acetyl-3-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]-2-methylene-5-oxohexanoic acid methyl ester

There total 2 articles about 4-acetyl-3-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]-2-methylene-5-oxohexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 123-54-6,81235-32-7
acetylacetone

: 627882-29-5
2-{acetoxy-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]methyl}acrylic acid methyl ester

: 884537-21-7
4-acetyl-3-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]-2-methylene-5-oxohexanoic acid methyl ester

Guidance literature:: 2-{acetoxy-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]methyl}acrylic acid methyl ester; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; at 20 ℃;

acetylacetone; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1080/01650420500328365

Reference yield:

: 627882-17-1
2-{[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylic acid methyl ester

: 884537-21-7
4-acetyl-3-[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]-2-methylene-5-oxohexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / CH₂Cl₂ / 20 °C

2.1: aq. DABCO / tetrahydrofuran / 20 °C

2.2: 82 percent / tetrahydrofuran; H₂O / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; dichloromethane;
DOI:10.1080/01650420500328365