4-((6-hydroxyhexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Base Information

• Chemical Name: 4-((6-hydroxyhexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide
• CAS No.: 901792-87-8
• Molecular Formula: C₁₄H₁₈N₂O₆S
• Molecular Weight: 342.373
• Mol file: 901792-87-8.mol

Synonyms:4-((6-hydroxyhexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Chemical Property of 4-((6-hydroxyhexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((6-hydroxyhexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

There total 2 articles about 4-((6-hydroxyhexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1,6-hexanediol (629-11-8) + 3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (66074-00-8) → 4-((6-hydroxyhexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (901792-87-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 5 ℃; for 0.5h;

DOI:10.1021/acs.jmedchem.5b00317

Reference yield:

(phenylthio)acetic acid (103-04-8) → 4-((6-hydroxyhexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (901792-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; dihydrogen peroxide / 3 h / 0 - 20 °C

1.2: 2 h / 0 - 110 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 4 h / 20 °C

With dihydrogen peroxide; acetic acid; sodium hydroxide; In tetrahydrofuran; water;

Reference yield: 89.5%

succinic acid anhydride (108-30-5) + 4-((6-hydroxyhexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (901792-87-8) → C18H22N2O9S (1186196-67-7)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 3h; Molecular sieve;

upstream raw materials:

1,6-hexanediol

3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

(phenylthio)acetic acid

Downstream raw materials:

3-(phenylsulfonyl)-4-(6-(2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoyloxy)hexyloxy)-1,2,5-oxadiazole-2-oxide

C₁₈H₂₂N₂O₉S

C₂₉H₃₅N₃O₁₀S

C₃₈H₄₅N₃O₁₂S