tert-butyl 4-(5-chloro-3-(((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenoxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(5-chloro-3-(((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenoxy)piperidine-1-carboxylate
CAS No.:1617501-04-8
Molecular Formula:C₂₆H₃₄ClN₃O₅
Molecular Weight:504.026
Hs Code.:

Synonyms:tert-butyl 4-(5-chloro-3-(((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenoxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(5-chloro-3-(((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenoxy)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(5-chloro-3-(((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenoxy)piperidine-1-carboxylate

There total 6 articles about tert-butyl 4-(5-chloro-3-(((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1617501-31-1
3-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)-5-chloro-2-methylbenzoic acid

: 1617501-16-2
3-amino-5-(aminomethyl)-2,6-dimethylpyridin-4(1H)-one hydrochloride

: 1617501-04-8
tert-butyl 4-(5-chloro-3-(((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenoxy)piperidine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1617501-04-8
tert-butyl 4-(5-chloro-3-(((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione / 2 h

2.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

3.1: thionyl chloride / 0.25 h / Cooling with ice

3.2: 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 75 °C

5.1: methanol; sodium hydroxide / 18 h / 55 °C

6.1: 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; methanol; copper(l) iodide; 8-quinolinol; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; sulfuric acid; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1549275-48-0
5-chloro-3-iodo-2-methylbenzoic acid

: 1617501-04-8
tert-butyl 4-(5-chloro-3-(((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

2.1: thionyl chloride / 0.25 h / Cooling with ice

2.2: 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 75 °C

4.1: methanol; sodium hydroxide / 18 h / 55 °C

5.1: 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; methanol; copper(l) iodide; 8-quinolinol; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;