(2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol

Base Information

Chemical Name:(2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol
CAS No.:410081-18-4
Molecular Formula:C₂₇H₃₇NO₇
Molecular Weight:487.593
Hs Code.:

Synonyms:(2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol

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Chemical Property of (2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol

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Technology Process of (2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol

There total 3 articles about (2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: tert-butyl-(4R)-4-((1R,2S)-1,2-di(4-methoxybenzyl)oxy-3-buten-1-yl)-2,2-dimethyl-3-oxazolidinecarboxylate

: 410081-18-4
(2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 9h;
DOI:10.1139/v01-133

Reference yield:

: 95715-87-0
(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine

: 410081-18-4
(2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / -78 °C

1.2: H₂O₂; KF; KHCO₃ / tetrahydrofuran; diethyl ether

2.1: 65 percent / NaH / dimethylformamide / 16 h / 0 - 20 °C

3.1: 90 percent / TsOH*H₂O / methanol / 9 h / 20 °C

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1139/v01-133

Reference yield:

: 135340-29-3
(4R)-tert-butyl 4-<(1R,2S)-1,2-dihydroxybut-3-enyl>-2,2-dimethyloxazolidine-3-carboxylate

: 410081-18-4
(2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / NaH / dimethylformamide / 16 h / 0 - 20 °C

2: 90 percent / TsOH*H₂O / methanol / 9 h / 20 °C

With sodium hydride; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1139/v01-133