(2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate

Base Information

Chemical Name:(2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate
CAS No.:1345202-60-9
Molecular Formula:C₂₃H₂₇FO₆S
Molecular Weight:450.528
Hs Code.:

Synonyms:(2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate

Suppliers and Price of (2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate

There total 4 articles about (2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345202-57-4
(2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl-2,2-dimethylpropanoate

: 98-59-9
p-toluenesulfonyl chloride

: 1345202-60-9
(2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate

Guidance literature:: With pyridine; at 10 - 15 ℃;

Reference yield:

: 129050-26-6,793669-26-8,876514-31-7
(2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-chromene

: 1345202-60-9
(2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 25 - 95 °C

2.1: potassium hydroxide; water / 100 - 105 °C

3.1: dichloromethane / 25 - 30 °C

3.2: 0 - 5 °C

4.1: pyridine / 10 - 15 °C

With pyridine; water; acetic acid; potassium hydroxide; In dichloromethane;

Reference yield:

: 303176-43-4
1-[6-fluoro-(2R)-3,4-dihydro-2H-benzopyran-2-yl]-(1S)-1,2-ethylene glycol

: 1345202-60-9
(2S)-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-tosyloxyethyl-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 25 - 30 °C

1.2: 0 - 5 °C

2.1: pyridine / 10 - 15 °C

With pyridine; In dichloromethane;