(R)-5-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide

Base Information

Chemical Name:(R)-5-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide
CAS No.:1020104-55-5
Molecular Formula:C₂₄H₂₄N₂O₅S₂
Molecular Weight:484.597
Hs Code.:

Synonyms:(R)-5-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide

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Chemical Property of (R)-5-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide

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Technology Process of (R)-5-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide

There total 7 articles about (R)-5-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1020104-53-3
5-Bromo-thiophene-2-sulfonic acid (1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-(R)-yl)-amide

: 5720-07-0
4-methoxyphenylboronic acid

: 1020104-55-5
(R)-5-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 - 150 ℃; for 0.333333h; sealed vessel; microwave irradiation;

Reference yield:

: 1020104-56-6
(R)-5-Bromo-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide

: 5720-07-0
4-methoxyphenylboronic acid

: 1020104-55-5
(R)-5-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide

Guidance literature:: With palladium diacetate; In N,N-dimethyl-formamide; at 150 ℃; Microwave irradiation;
DOI:10.1016/j.bmcl.2011.08.068

Reference yield:

: 1020104-29-3
(+)-[1-(allyl-benzyloxy-carbamoyl)-but-3-(R)-enyl]-carbamic acid tert-butyl ester

: 1020104-55-5
(R)-5-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 8 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: pyridine / dichloromethane / 20 °C

4: palladium diacetate / N,N-dimethyl-formamide / 150 °C / Microwave irradiation

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium diacetate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.08.068