(R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride

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Chemical Name:(R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride
CAS No.:1181690-16-3
Molecular Formula:C₂₄H₃₀N₂O₂*ClH
Molecular Weight:414.975
Hs Code.:

Synonyms:(R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride

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Chemical Property of (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride

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Technology Process of (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride

There total 7 articles about (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849519-42-2
(R)-1-[2-(4-bromo-phenyl)-ethyl]-2-methyl-pyrrolidine

: 1181690-67-4
2-hydroxy-1-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

: 1181690-16-3
(R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride

Guidance literature:: (R)-1-[2-(4-bromo-phenyl)-ethyl]-2-methyl-pyrrolidine; 2-hydroxy-1-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone; With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; toluene; at 60 ℃; for 2h;

With hydrogenchloride; In ethanol; at 15 ℃; for 0.333333h;

Reference yield:

: 79-14-1
glycolic Acid

: 1181690-12-9
(R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

: 1181690-16-3
(R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride

Guidance literature:: glycolic Acid; (R)-6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline; With PS-carbodiimide; triethylamine; In dichloromethane; at 20 ℃;

With hydrogenchloride; In diethyl ether;

Reference yield:

: 226942-29-6
6-bromo-1,2,3,4-tetrahydroisoquinoline

: 1181690-16-3
(R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 20 h / Reflux

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 3 h / Reflux

2.2: 10 - 20 °C

With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; 2.1: Suzuki Coupling;