2-Phenyl-6-morpholinopyridine

Base Information

Chemical Name:2-Phenyl-6-morpholinopyridine
CAS No.:332134-61-9
Molecular Formula:C₁₅H₁₆N₂O
Molecular Weight:240.305
Hs Code.:
DSSTox Substance ID:DTXSID901297740

Synonyms:2-phenyl-6-morpholinopyridine;SCHEMBL6378776;GUUWRLBALIXDFK-UHFFFAOYSA-N;DTXSID901297740;4-(6-Phenyl-2-pyridinyl)morpholine;332134-61-9

Suppliers and Price of 2-Phenyl-6-morpholinopyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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price

Total 0 raw suppliers

Chemical Property of 2-Phenyl-6-morpholinopyridine

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:240.126263138
Heavy Atom Count:18
Complexity:247

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1C2=CC=CC(=N2)C3=CC=CC=C3

Technology Process of 2-Phenyl-6-morpholinopyridine

There total 4 articles about 2-Phenyl-6-morpholinopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1078-58-6
diphenylzinc

: 332134-60-8
4-(6-bromopyridin-2-yl)morpholine

: 332134-61-9
4-(6-phenylpyridin-2-yl)morpholine

Guidance literature:: With tripiperidino-phosphine; nickel dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 100 ℃; for 1h;
DOI:10.1002/chem.201101037

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 180606-17-1
2-fluoro-6-phenyl-pyridine

: 332134-61-9
4-(6-phenylpyridin-2-yl)morpholine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 100 ℃; Inert atmosphere; Glovebox; Sealed tube;
DOI:10.1021/ja5049303

Reference yield:

: 1008-89-5
2-phenylpyridine

: 332134-61-9
4-(6-phenylpyridin-2-yl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: silver(II) fluoride / acetonitrile / 1 h / 20 °C / Inert atmosphere; Glovebox; Sealed tube

2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 20 - 100 °C / Inert atmosphere; Glovebox; Sealed tube

With silver(II) fluoride; sodium hydride; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/ja5049303