8-Quinolineethanol

Base Information

• Chemical Name: 8-Quinolineethanol
• CAS No.: 73048-42-7
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.214
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID80449574
• Wikidata: Q82269091
• Mol file: 73048-42-7.mol

Synonyms:8-Quinolineethanol;73048-42-7;2-quinolin-8-ylethanol;2-(quinolin-8-yl)ethan-1-ol;SCHEMBL11497495;DTXSID80449574;AKOS006310968;EN300-1626642

Chemical Property of 8-Quinolineethanol

Chemical Property:

• PSA: 33.12000
• LogP: 1.76960
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 173.084063974
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

8-Quinolineethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C1)CCO)N=CC=C2

Technology Process of 8-Quinolineethanol

There total 4 articles about 8-Quinolineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

quinoline-8-sulfonic acid 2-bromo-ethyl ester → ethyl-8-quinoline sulfonate (313996-78-0) + 8-(2-Hydroxyethyl)quinoline (73048-42-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 12h; Heating;

DOI:10.1039/b303728b

Reference yield:

8-quinolinesulfonic acid (85-48-3) → 8-(2-Hydroxyethyl)quinoline (73048-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / Et₃N / CH₂Cl₂ / ice-cooling

2: 63 percent / AIBN; Bu₃SnH / benzene / 12 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In dichloromethane; benzene;

DOI:10.1039/b303728b

Reference yield:

2-bromoaniline (615-36-1) → 8-(2-Hydroxyethyl)quinoline (73048-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Sulfuric acid, iodine

With sulfuric acid; iodine;

DOI:10.1021/jo01296a035

upstream raw materials:

oxirane

8-bromoquinoline

8-quinolinesulfonic acid

2-bromoaniline

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