7-iodo-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:7-iodo-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one
CAS No.:116725-45-2
Molecular Formula:C₁₆H₁₂ClIN₂O
Molecular Weight:410.642
Hs Code.:

Synonyms:7-iodo-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one

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Chemical Property of 7-iodo-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one

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Technology Process of 7-iodo-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one

There total 5 articles about 7-iodo-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 116725-43-0
7-iodo-1,3-dihydro-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one

: 74-88-4
methyl iodide

: 116725-45-2
7-iodo-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; 1.) 0 deg C to 5 deg C, room temperature, 30 min, 2.) room temperature;
DOI:10.1021/jm00119a005

Reference yield:

: 623-03-0
4-Cyanochlorobenzene

: 116725-45-2
7-iodo-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / 1.) BCl₃, 2.) AlCl₃ / 1,2-dichloro-ethane; CH₂Cl₂ / 1.) 0 deg C, 2.) room temperature, 30 min, room temperature to 60 deg C, 78 deg C, 6 h

2: aq. HCl / 0.5 h / 78 °C

3: 76 percent / pyridine / 15 h / Heating

4: 95 percent / 1.) NaH / dimethylformamide / 1.) 0 deg C to 5 deg C, room temperature, 30 min, 2.) room temperature

With hydrogenchloride; aluminium trichloride; boron trichloride; sodium hydride; In pyridine; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a005

Reference yield:

: 116725-41-8
5-iodo-2-amino-4'-chlorobenzophenone

: 116725-45-2
7-iodo-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / pyridine / 15 h / Heating

2: 95 percent / 1.) NaH / dimethylformamide / 1.) 0 deg C to 5 deg C, room temperature, 30 min, 2.) room temperature

With sodium hydride; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jm00119a005