4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine

Base Information

Chemical Name:4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine
CAS No.:494213-18-2
Molecular Formula:C₂₂H₃₃F₂NO
Molecular Weight:365.507
Hs Code.:

Synonyms:4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine

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Chemical Property of 4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine

Chemical Property:

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Technology Process of 4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine

There total 3 articles about 4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 494213-17-1
1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene

: 494213-18-2
4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; methanol; at 20 ℃; for 24h; Sealed tube;
DOI:10.1002/ejoc.201301067

Reference yield:

: 65355-32-0
trans-4-(trans-4'-n-propylcyclohexyl)cyclohexanecarboxylic acid

: 494213-18-2
4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene; 2,2,4-trimethylpentane / 2 h / 102 - 104 °C

2.1: triethylamine / dichloromethane / 1.5 h / -70 °C

2.2: -70 °C

2.3: -70 - 0 °C

3.1: zinc; ammonium chloride / methanol; tetrahydrofuran / 24 h / 20 °C / Sealed tube

With ammonium chloride; triethylamine; zinc; In tetrahydrofuran; methanol; 2,2,4-trimethylpentane; dichloromethane; toluene;
DOI:10.1002/ejoc.201301067

Reference yield:

: 5,6-dihydro-2-[(trans,trans)-4-(4-propylcyclohexyl)cyclohexyl]-4H-1,3-dithiinium trifluoromethanesulfonate

: 494213-18-2
4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 1.5 h / -70 °C

1.2: -70 °C

1.3: -70 - 0 °C

2.1: zinc; ammonium chloride / methanol; tetrahydrofuran / 24 h / 20 °C / Sealed tube

With ammonium chloride; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ejoc.201301067