1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene

Base Information

Chemical Name:1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene
CAS No.:494213-17-1
Molecular Formula:C₂₂H₃₁F₂NO₃
Molecular Weight:395.49
Hs Code.:

Synonyms:1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene

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Chemical Property of 1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene

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Technology Process of 1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene

There total 2 articles about 1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 5,6-dihydro-2-[(trans,trans)-4-(4-propylcyclohexyl)cyclohexyl]-4H-1,3-dithiinium trifluoromethanesulfonate

: 494213-17-1
1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene

Guidance literature:: 4-nitro-phenol; 5,6-dihydro-2-[(trans,trans)-4-(4-propylcyclohexyl)cyclohexyl]-4H-1,3-dithiinium trifluoromethanesulfonate; With triethylamine; In dichloromethane; at -70 ℃; for 1.5h;

With triethylamine tris(hydrogen fluoride); In dichloromethane; at -70 ℃;

With bromine; In dichloromethane; at -70 - 0 ℃;
DOI:10.1002/ejoc.201301067

Reference yield:

: 65355-32-0
trans-4-(trans-4'-n-propylcyclohexyl)cyclohexanecarboxylic acid

: 494213-17-1
1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene; 2,2,4-trimethylpentane / 2 h / 102 - 104 °C

2.1: triethylamine / dichloromethane / 1.5 h / -70 °C

2.2: -70 °C

2.3: -70 - 0 °C

With triethylamine; In 2,2,4-trimethylpentane; dichloromethane; toluene;
DOI:10.1002/ejoc.201301067