C₁₆H₁₉F₂IO₃

Base Information

• Chemical Name: C₁₆H₁₉F₂IO₃
• CAS No.: 1350560-52-9
• Molecular Formula: C₁₆H₁₉F₂IO₃
• Molecular Weight: 424.226
• Mol file: 1350560-52-9.mol

Synonyms:C₁₆H₁₉F₂IO₃

Chemical Property of C₁₆H₁₉F₂IO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₉F₂IO₃

There total 6 articles about C₁₆H₁₉F₂IO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methylpropanoic acid [(2S)-4-(2,4-difluorophenyl)-2-hydroxymethyl-4-penten-1-yl] ester (192448-07-0) → C16H19F2IO3 (1350560-52-9)

Guidance literature:

With iodine; sodium hydrogencarbonate; In ethyl acetate; at -15 ℃; for 5h;

Reference yield:

2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) → C16H19F2IO3 (1350560-52-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: magnesium / tert-butyl methyl ether / 4 h / 55 °C

1.2: -10 - 0 °C

1.3: 3 h / 25 - 50 °C

2.1: sodium hydroxide / dimethyl sulfoxide / 5 h / 25 - 30 °C

3.1: water; lithium chloride; sodium tetrahydroborate / isopropyl alcohol / 20 h / -5 - 30 °C

3.2: pH 1

4.1: sodium hydrogencarbonate / toluene / 24 h / -15 °C / Enzymatic reaction

5.1: sodium hydrogencarbonate; iodine / ethyl acetate / 5 h / -15 °C

With sodium tetrahydroborate; water; iodine; sodium hydrogencarbonate; magnesium; lithium chloride; sodium hydroxide; In tert-butyl methyl ether; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

2-[2-(2,4-difluorophenyl)-2-propene-1-yl]-1, 3-propanediol (165115-73-1) → C16H19F2IO3 (1350560-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / toluene / 24 h / -15 °C / Enzymatic reaction

2: sodium hydrogencarbonate; iodine / ethyl acetate / 5 h / -15 °C

With iodine; sodium hydrogencarbonate; In ethyl acetate; toluene;

upstream raw materials:

2-chloro-1-(2,4-dichlorophenyl)ethanone

2-[2-(2,4-difluorophenyl)-2-propene-1-yl]-1, 3-propanediol

2-methylpropanoic acid [(2S)-4-(2,4-difluorophenyl)-2-hydroxymethyl-4-penten-1-yl] ester

1-(1-chloromethylethenyl)-2,4-difluorobenzene

Downstream raw materials:

posaconazote

(2R-cis)-2-(2,4-difluorophenyl)-4-[[(4-methylphenyl)sulfonyloxy]methyl]-2-[(1H-1,2,4-triazol-1-yl)methyl]tetrahydrofuran

C₃₀H₃₂F₂N₆O₂

C₃₇H₄₄F₂N₈O₅