1-(1-chloromethylethenyl)-2,4-difluorobenzene

Base Information

• Chemical Name: 1-(1-chloromethylethenyl)-2,4-difluorobenzene
• CAS No.: 156570-10-4
• Molecular Formula: C₉H₇ClF₂
• Molecular Weight: 188.604
• Mol file: 156570-10-4.mol

Synonyms:1-(1-chloromethylethenyl)-2,4-difluorobenzene

Chemical Property of 1-(1-chloromethylethenyl)-2,4-difluorobenzene

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-chloromethylethenyl)-2,4-difluorobenzene

There total 6 articles about 1-(1-chloromethylethenyl)-2,4-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) + (trimethylsilyl)methylmagnesium chloride (13170-43-9) → 1-(1-chloromethylethenyl)-2,4-difluorobenzene (156570-10-4)

Guidance literature:

(trimethylsilyl)methylmagnesium chloride; With magnesium; Chloromethyltrimethylsilane; In tert-butyl methyl ether; at 55 ℃; for 4h;

2-chloro-1-(2,4-dichlorophenyl)ethanone; In tert-butyl methyl ether; at -10 - 0 ℃;

With sulfuric acid; at 25 - 50 ℃; for 3h;

Reference yield: 95.0%

2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) + (trimethylsilyl)methylmagnesium chloride (13170-43-9) + Chloromethyltrimethylsilane (2344-80-1) → 1-(1-chloromethylethenyl)-2,4-difluorobenzene (156570-10-4)

Guidance literature:

(trimethylsilyl)methylmagnesium chloride; Chloromethyltrimethylsilane; With magnesium; In tert-butyl methyl ether; at 55 ℃; for 4h;

2-chloro-1-(2,4-dichlorophenyl)ethanone; In tert-butyl methyl ether; at -10 - 0 ℃;

With sulfuric acid; In tert-butyl methyl ether; at 25 - 50 ℃; for 3h;

Reference yield: 90.0%

1,3-dichloro-2-(2,4-difluorophenyl)propane → 1-(1-chloromethylethenyl)-2,4-difluorobenzene (156570-10-4)

Guidance literature:

With potassium hydroxide; tert-butyl alcohol; for 5h; Reagent/catalyst; Reflux;

upstream raw materials:

2-chloro-1-(2,4-dichlorophenyl)ethanone

(trimethylsilyl)methylmagnesium chloride

Chloromethyltrimethylsilane

2-(2,4-difluorophenyl)allyl alcohol

Downstream raw materials:

diethyl 2-[2-(2,4-difluorophenyl)-2-propen-1-yl]-1,3-propanedioate

posaconazote

2-[2-(2,4-difluorophenyl)-2-propene-1-yl]-1, 3-propanediol

2-methylpropanoic acid [(2S)-4-(2,4-difluorophenyl)-2-hydroxymethyl-4-penten-1-yl] ester