4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-hydroxy-2-methylbutyl}amino)piperidine-1-carboxylate

Base Information

Chemical Name:4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-hydroxy-2-methylbutyl}amino)piperidine-1-carboxylate
CAS No.:888228-45-3
Molecular Formula:C₂₃H₃₄F₄N₂O₃
Molecular Weight:462.528
Hs Code.:

Synonyms:4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-hydroxy-2-methylbutyl}amino)piperidine-1-carboxylate

Suppliers and Price of 4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-hydroxy-2-methylbutyl}amino)piperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-hydroxy-2-methylbutyl}amino)piperidine-1-carboxylate

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Technology Process of 4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-hydroxy-2-methylbutyl}amino)piperidine-1-carboxylate

There total 2 articles about 4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-hydroxy-2-methylbutyl}amino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1,1-dimethylethyl 4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-oxobutyl}amino)piperidine-1-carboxylate

: 676-58-4
methylmagnesium chloride

: 888228-45-3
4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-hydroxy-2-methylbutyl}amino)piperidine-1-carboxylate

Guidance literature:: In tetrahydrofuran;
DOI:10.1016/j.bmcl.2006.02.008

Reference yield:

: 710981-79-6
4-(4-fluoro-2-trifluoromethyl-benzylamino)-piperidine-l-carboxylic acid tert-butyl ester

: 888228-45-3
4-({[4-fluoro-2-(trifluoromethyl)phenyl]methyl}{2-hydroxy-2-methylbutyl}amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / CHCl₃

2: 92 percent / tetrahydrofuran

In tetrahydrofuran; chloroform; 2: Grignard reaction;
DOI:10.1016/j.bmcl.2006.02.008