123004-73-9

Upstream product

• 123004-72-8 D-glycine tert-butyl ester toluenesulfonate salt 
• 111216-46-7 tert-butyl N-(4,5-diphenyl-4-oxazolin-2-onyl)-L-seryl-D-glycinate 
• 110207-46-0 (-)-3-N-(4,5-diphenyl-4-oxazolin-2-onyl)aminocardicinic acid tert-butyl ester 

Downstream Products

• 110207-48-2 (R)-{(S)-3-[(R)-2-tert-Butoxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-2-oxo-azetidin-1-yl}-(4-hydroxy-phenyl)-acetic acid tert-butyl ester 
• 65309-11-7 (-)-nocardicin G 
• 110269-45-9 di-tert-butyl N-(tert-butoxycarbonyl)nocardicin A 
• 39391-39-4 (-)-nocardicin A 
• 1443793-39-2 nocardicin G-pantetheine trifluoroacetate 
• 1443793-41-6 epi-nocardicin G-SNAC 
• 1443793-43-8 nocardicin G-SNAC 
• 121787-02-8 N-(tert-butyloxycarbonyl)nocardicin G 
• 61425-17-0 (-)-nocardicin D 
• 60134-71-6 (-)-nocardicin B 
• 123004-77-3 (R)-4-[4-((R)-Amino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester; hydrochloride 
• 99297-17-3 (-)-nocardicin C 
• 123004-76-2 (R)-4-[4-((R)-Benzyloxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-2-tert-butoxycarbonylamino-butyric acid tert-butyl ester 
• 123004-80-8 (R)-2-tert-Butoxycarbonylamino-4-[4-((R)-tert-butoxycarbonylamino-{(S)-1-[(R)-tert-butoxycarbonyl-(4-hydroxy-phenyl)-methyl]-2-oxo-azetidin-3-ylcarbamoyl}-methyl)-phenoxy]-butyric acid tert-butyl ester 

Relevant academic research and scientific papers

Stereocontrolled syntheses of peptide thioesters containing modified seryl residues as probes of antibiotic biosynthesis

Methods have been developed to synthesize tri- and pentapeptide thioesters containing one or more p-(hydroxyphenyl)glycine (pHPG) residues and l-serine, some where the latter is O-phosphorylated, O-acetylated, or exists as a β-lactam. Selection of orthogo

Total syntheses of (-)-nocardicins A-G: A biogenetic approach

The known nocardicins A-G have been synthesized, several for the first time, having geometric and stereoisomeric purities of a high order. The syntheses proceed through the central intermediacy of tert-butyl (-)-3-aminocardicinate (14), which has been pre

BIOGENETICALLY-MODELLED TOTAL SYNTHESES (-)-NOCARDICIN A AND (-)-NOCARDICIN G

A protected form of L-seryl-D-(p-hydroxyphenyl)glycine was cyclized in a biogenetic sense and partially deprotected to give (-)-t-butyl 3-amino nocardicinate (5) from which (-)-nocardicin A (1) and (-)-nocardicin G (11) were prepared.