N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt

Base Information

• Chemical Name: N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt
• CAS No.: 1365543-64-1
• Molecular Formula: C₆H₆O₃S*C₂₇H₂₆F₆N₄O₄S
• Molecular Weight: 774.762

Synonyms:N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt

Chemical Property of N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt

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Technology Process of N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt

There total 10 articles about N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-{[(1R,2R)-2-(benzyloxy)-1-methylpropyl]oxy}-2-chloro-5-(trifluoromethyl)pyrimidine (1223498-50-7) + N-[(R)-(4-aminophenyl)(cyclopropyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide (1365543-92-5) + benzenesulfonic acid (98-11-3) → N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt (1365543-64-1)

Guidance literature:

In 1,4-dioxane; at 20 - 60 ℃; for 35h;

Reference yield:

cyclopropyl(imino)(4-nitrophenyl)-λ6-sulfanone (942410-33-5) → N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt (1365543-64-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetonitrile / 16 h / 20 °C

2.1: potassium carbonate / water; dichloromethane / 1 h / 20 °C

2.2: 0.83 h / 20 - 25 °C

3.1: iron-doped palladium on carbon; hydrogen / methanol; water / 7 h / 1875.19 Torr

4.1: 1,4-dioxane / 35 h / 20 - 60 °C

With iron-doped palladium on carbon; hydrogen; potassium carbonate; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;

Reference yield:

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid 1-(R)-(cyclopropylsulphonimidoyl)-4-nitrobenzene (1365544-29-1) → N-[(4-{[4-{[(2R,3R)-3-(benzyloxy)butan-2-yl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)(cyclopropyl)oxido-lambda6-sulphanylidene]-2,2,2-trifluoroacetamide benzenesulphonic acid salt (1365543-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / water; dichloromethane / 1 h / 20 °C

1.2: 0.83 h / 20 - 25 °C

2.1: iron-doped palladium on carbon; hydrogen / methanol; water / 7 h / 1875.19 Torr

3.1: 1,4-dioxane / 35 h / 20 - 60 °C

With iron-doped palladium on carbon; hydrogen; potassium carbonate; In 1,4-dioxane; methanol; dichloromethane; water;

upstream raw materials:

N-[cyclopropyl(4-nitrophenyl)-lambda⁴-sulphanylidene]-2,2,2-trifluoroacetamide

cyclopropyl(imino)(4-nitrophenyl)-λ⁶-sulfanone

(2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid 1-(R)-(cyclopropylsulphonimidoyl)-4-nitrobenzene

N-[(R)-cyclopropyl(4-nitrophenyl)oxido-lambda⁶-sulphanylidene]-2,2,2-trifluoroacetamide

Downstream raw materials:

(R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide

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