benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate

Base Information

Chemical Name:benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate
CAS No.:1363375-96-5
Molecular Formula:C₃₀H₂₉FN₂O₆S
Molecular Weight:564.634
Hs Code.:

Synonyms:benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate

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Chemical Property of benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate

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Technology Process of benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate

There total 7 articles about benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1363375-41-0
ethyl [2-amino-2-[1-(4-fluorophenyl)-2-methyl-5-(4-methanesulphonylphenyl)-1H-pyrrol-3-yl]]-acetate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1363375-96-5
benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate

Guidance literature:: With sodium carbonate; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.ejmech.2012.10.014

Reference yield:

: ethyl 2-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]glyoxylate

: 1363375-96-5
benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; 1,4-dioxane / 40 h / 90 °C

2: zinc; formic acid / ethanol / 0 - 20 °C

3: sodium carbonate / dichloromethane / 4 h / 0 - 20 °C

With formic acid; hydroxylamine hydrochloride; sodium acetate; sodium carbonate; zinc; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2012.10.014

Reference yield:

: 189500-90-1
1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole

: 1363375-96-5
benzyl N-((ethoxycarbonyl)-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium acetate / ethanol; 1,4-dioxane / 40 h / 90 °C

3: zinc; formic acid / ethanol / 0 - 20 °C

4: sodium carbonate / dichloromethane / 4 h / 0 - 20 °C

With formic acid; hydroxylamine hydrochloride; sodium acetate; titanium tetrachloride; sodium carbonate; zinc; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2012.10.014