(S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate

Base Information

Chemical Name:(S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate
CAS No.:1580438-23-8
Molecular Formula:C₂₆H₃₄N₂O₄
Molecular Weight:438.567
Hs Code.:

Synonyms:(S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate

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Chemical Property of (S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate

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Technology Process of (S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate

There total 6 articles about (S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1580440-92-1
2-(4'-(2-methoxyethoxy)-[1,1'-biphenyl]-4-yl)-2-methylpropanoic acid

: 3684-26-2,25333-42-0,34583-34-1,1619-34-7
(S)-quinuclidin-3-ol

: 1580438-23-8
(S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate

Guidance literature:: 2-(4'-(2-methoxyethoxy)-[1,1'-biphenyl]-4-yl)-2-methylpropanoic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 1h;

With sodium azide; In tetrahydrofuran; water; at 0 - 20 ℃;

(S)-quinuclidin-3-ol; Further stages;

Reference yield:

: C₁₉H₂₁N₃O₃

: 3684-26-2,25333-42-0,34583-34-1,1619-34-7
(S)-quinuclidin-3-ol

: 1580438-23-8
(S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate

Guidance literature:: C₁₉H₂₁N₃O₃; In toluene; Reflux;

(S)-quinuclidin-3-ol; In toluene; Reflux;

Reference yield:

: 32454-36-7
2-(4-bromophenyl)-2-methyl-propionic acid ethyl ester

: 1580438-23-8
(S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 90 °C

2.1: water; lithium hydroxide monohydrate / ethanol; tetrahydrofuran / Reflux

3.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 1 h / 0 °C

3.2: 0 - 20 °C

4.1: toluene / Reflux

4.2: Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; water; sodium carbonate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; ethanol; water; toluene; 1.1: |Suzuki Coupling / 4.1: |Curtius Rearrangement / 4.2: |Curtius Rearrangement;