32454-36-7

Basic information

• Product Name: ethyl 2-(4-broMophenyl)-2-Methylpropanoate
• Synonyms: ethyl 2-(4-broMophenyl)-2-Methylpropanoate
• CAS NO: 32454-36-7
• Molecular Formula: C₁₂H₁₅BrO₂
• Molecular Weight: 271.1503
• Mol File: 32454-36-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ethyl 2-(4-broMophenyl)-2-Methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-broMophenyl)-2-Methylpropanoate(32454-36-7)
• EPA Substance Registry System: ethyl 2-(4-broMophenyl)-2-Methylpropanoate(32454-36-7)

Safety Data

• Hazardous Substances Data: 32454-36-7(Hazardous Substances Data)

Usage

Uses

Ethyl 2-?(4-?Bromophenyl)?-?2-?methylpropanoate is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Upstream product

• 14062-25-0 Ethyl 4-bromophenylacetate 
• 74-88-4 methyl iodide 
• 629-14-1 monoethylene glycol diethyl ether 

Downstream Products

• 1580438-23-8 (S)-quinuclidin-3-yl (2-(4’-(2-methoxyethoxy)-[1,1‘-biphenyl]-4-yl)propan-2-yl)carbamate 
• 1428718-45-9 1-bromo-4-(1-fluoro-2-methylpropan-2-yl)benzene 
• 1428718-74-4 (S)-3-(4-bromophenyl)-1,1,1-trifluoro-3-methylbutan-2-ol 
• 1428718-75-5 (R)-3-(4-bromophenyl)-1,1,1-trifluoro-3-methylbutan-2-ol 
• 145208-47-5 2-(4-Bromophenyl)-2-methylpropyl methyl ether 
• 32454-35-6 2-(4-bromophenyl)-2-methylpropionic acid 
• 1067515-56-3 ethyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate 
• 32454-16-3 2-(4-bromophenyl)-2-methyl-propionaldehyde 
• 35462-92-1 3-(4-Bromo-phenyl)-2,3-dimethyl-butan-2-ol 

Relevant articles and documents

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

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