2,2-dichloro-N-[2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4[2-(trimethylsilyl)ethynyl]phenyl]acetamide

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Chemical Name:2,2-dichloro-N-[2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4[2-(trimethylsilyl)ethynyl]phenyl]acetamide
CAS No.:1299312-82-5
Molecular Formula:C₂₂H₁₈Cl₂F₃N₃O₂Si
Molecular Weight:512.391
Hs Code.:

Synonyms:2,2-dichloro-N-[2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4[2-(trimethylsilyl)ethynyl]phenyl]acetamide

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Chemical Property of 2,2-dichloro-N-[2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4[2-(trimethylsilyl)ethynyl]phenyl]acetamide

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Technology Process of 2,2-dichloro-N-[2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4[2-(trimethylsilyl)ethynyl]phenyl]acetamide

There total 6 articles about 2,2-dichloro-N-[2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4[2-(trimethylsilyl)ethynyl]phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 79-36-7
dichloroacethyl chloride

: 1299312-81-4
2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4-[2-(trimethylsilyl)ethynyl]aniline

: 1299312-82-5
2,2-dichloro-N-[2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4[2-(trimethylsilyl)ethynyl]phenyl]acetamide

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 0.666667h;

Reference yield:

: 1066-54-2
trimethylsilylacetylene

: 1299312-82-5
2,2-dichloro-N-[2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4[2-(trimethylsilyl)ethynyl]phenyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere; Darkness

2.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 16 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 2 h / -80 °C / Inert atmosphere; Cooling with ether-dry ice

4.1: manganese(IV) oxide / diethyl ether / 30 h / 20 °C

5.1: dichloromethane / 0.67 h / 0 - 20 °C

With 4-methyl-morpholine; manganese(IV) oxide; n-butyllithium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; hexanes; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5326-47-6
2-amino-5-iodobenzoic acid

: 1299312-82-5
2,2-dichloro-N-[2-({4-[3-(trifluoromethyl)diazirin-3-yl]phenyl}carbonyl)-4[2-(trimethylsilyl)ethynyl]phenyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere; Darkness

2.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 16 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 2 h / -80 °C / Inert atmosphere; Cooling with ether-dry ice

4.1: manganese(IV) oxide / diethyl ether / 30 h / 20 °C

5.1: dichloromethane / 0.67 h / 0 - 20 °C

With 4-methyl-morpholine; manganese(IV) oxide; n-butyllithium; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; hexanes; diethyl ether; dichloromethane; N,N-dimethyl-formamide;