2-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-5-(p-tolyl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-5-(p-tolyl)-1,3,4-oxadiazole
CAS No.:1260218-02-7
Molecular Formula:C₁₅H₁₅N₅O₃S
Molecular Weight:345.382
Hs Code.:

Synonyms:2-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-5-(p-tolyl)-1,3,4-oxadiazole

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Chemical Property of 2-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-5-(p-tolyl)-1,3,4-oxadiazole

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Technology Process of 2-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-5-(p-tolyl)-1,3,4-oxadiazole

There total 3 articles about 2-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-5-(p-tolyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.1%

: 31130-15-1
2-mercapto-5-(4-methylphenyl)-1,3,4-oxadiazole

: 6058-57-7
1-(2-bromoethyl)-2-methyl-5-nitroimidazole

: 1260218-02-7
2-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-5-(p-tolyl)-1,3,4-oxadiazole

Guidance literature:: With sodium ethanolate; In ethanol; Reflux;
DOI:10.1016/j.bmc.2013.02.008

Reference yield:

: 443-48-1
metronidazole

: 1260218-02-7
2-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-5-(p-tolyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine; phosphorus trichloride / ethyl acetate / 3 h / Reflux

1.2: pH 5 - 6

2.1: sodium ethanolate / ethanol / Reflux

With bromine; sodium ethanolate; phosphorus trichloride; In ethanol; ethyl acetate;
DOI:10.1016/j.bmc.2013.02.008

Reference yield:

: 99-94-5
p-Toluic acid

: 1260218-02-7
2-((2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-5-(p-tolyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid

2: hydrazine hydrate / ethanol / Reflux

3: potassium hydroxide / ethanol / Reflux

4: sodium ethanolate / ethanol / Reflux

With sulfuric acid; sodium ethanolate; hydrazine hydrate; potassium hydroxide; In ethanol;
DOI:10.1016/j.bmc.2013.02.008