6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

Base Information

Chemical Name:6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide
CAS No.:521070-56-4
Molecular Formula:C₂₆H₂₃FN₄O
Molecular Weight:426.493
Hs Code.:

Synonyms:6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

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Chemical Property of 6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

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Technology Process of 6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

There total 6 articles about 6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 223127-24-0
6-(4-fluorophenyl)-pyridine-3-carboxylic acid

: 521073-96-1
3-(1-pyrrolidinylmethyl)-7-quinolinylamine hydrochloride

: 521070-56-4
6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

Guidance literature:: With dmap; ethylene dichloride hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Cooling with ice;
DOI:10.1021/jm201596h

Reference yield:

: 1361537-86-1
N-[3-(pyrrolidin-1-ylmethyl)-7-quinolinyl]acetamide

: 521070-56-4
6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1 h / 100 °C

2: dmap; ethylene dichloride hydrochloride; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; ethylene dichloride hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm201596h

Reference yield:

: 521073-92-7
N-[3-(hydroxymethyl)-7-quinolinyl]acetamide

: 521070-56-4
6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2 h / 20 °C

2: potassium carbonate / acetonitrile / 2 h / 80 °C

3: hydrogenchloride / 1 h / 100 °C

4: dmap; ethylene dichloride hydrochloride; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; thionyl chloride; ethylene dichloride hydrochloride; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm201596h