Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide]

Base Information

Chemical Name:Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide]
CAS No.:188058-83-5
Molecular Formula:C₄₇H₆₀N₈O₄S₂
Molecular Weight:865.177
Hs Code.:

Synonyms:Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide]

Suppliers and Price of Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide]

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Technology Process of Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide]

There total 7 articles about Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142-79-0
pimeloyl chloride

: 188058-83-5
Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide]

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / pyridine / 1) 0 deg C, 1 h; 2) rt, 7 h

2: 88 percent / H₂ / act. Ni / ethanol / 5 h / 80 °C / 75006 Torr

3: 1-ethylpiperidine / tetrahydrofuran / 1) 0 deg C, 1 h; 2) rt, 30 min

4: tetrahydrofuran / 4 h / Heating

With 1-ethyl-piperidine; pyridine; hydrogen; nickel; In tetrahydrofuran; ethanol;
DOI:10.1016/S0223-5234(97)84360-7

Reference yield:

: 22948-02-3
3-aminothiophenol

: 188058-83-5
Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide]

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / sodium acetate / ethanol / 36 h / Heating

2: 93 percent / pyridine / 1) 0 deg C, 1 h; 2) rt, 7 h

3: 88 percent / H₂ / act. Ni / ethanol / 5 h / 80 °C / 75006 Torr

4: 1-ethylpiperidine / tetrahydrofuran / 1) 0 deg C, 1 h; 2) rt, 30 min

5: tetrahydrofuran / 4 h / Heating

With 1-ethyl-piperidine; pyridine; hydrogen; sodium acetate; nickel; In tetrahydrofuran; ethanol;
DOI:10.1016/S0223-5234(97)84360-7

Reference yield:

: 93352-49-9
4-amino-2'-nitrodiphenyl sulfide

: 188058-83-5
Heptanedioic acid bis-[(3-{2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenyl)-amide]

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / pyridine / 1) 0 deg C, 1 h; 2) rt, 7 h

2: 88 percent / H₂ / act. Ni / ethanol / 5 h / 80 °C / 75006 Torr

3: 1-ethylpiperidine / tetrahydrofuran / 1) 0 deg C, 1 h; 2) rt, 30 min

4: tetrahydrofuran / 4 h / Heating

With 1-ethyl-piperidine; pyridine; hydrogen; nickel; In tetrahydrofuran; ethanol;
DOI:10.1016/S0223-5234(97)84360-7