4-Methyl-N-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-(toluene-4-sulfonyl)-butyl]-benzenesulfonamide

Base Information

• Chemical Name: 4-Methyl-N-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-(toluene-4-sulfonyl)-butyl]-benzenesulfonamide
• CAS No.: 106369-26-0
• Molecular Formula: C₂₃H₃₁NO₆S₂
• Molecular Weight: 481.634

Synonyms:4-Methyl-N-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-(toluene-4-sulfonyl)-butyl]-benzenesulfonamide

Chemical Property of 4-Methyl-N-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-(toluene-4-sulfonyl)-butyl]-benzenesulfonamide

Chemical Property:

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Technology Process of 4-Methyl-N-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-(toluene-4-sulfonyl)-butyl]-benzenesulfonamide

There total 2 articles about 4-Methyl-N-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-(toluene-4-sulfonyl)-butyl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-Methyl-2-[2-(toluene-4-sulfonyl)-butyl]-[1,3]dioxolane (106369-13-5) + N-(p-toluenesulfonylmethyl)-p-toluenesulfonamide (41369-60-2) → 4-Methyl-N-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-(toluene-4-sulfonyl)-butyl]-benzenesulfonamide (106369-26-0)

Guidance literature:

With n-butyllithium; methyllithium; In tetrahydrofuran; at -78 ℃;

DOI:10.1246/cl.1986.1033

Reference yield:

toluene-4-sulfonamide (70-55-3) → 4-Methyl-N-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-(toluene-4-sulfonyl)-butyl]-benzenesulfonamide (106369-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / formic acid; H₂O / 2 h / 80 °C

2: 71 percent / MeLi, BuLi / tetrahydrofuran / -78 °C

With n-butyllithium; methyllithium; In tetrahydrofuran; formic acid; water;

DOI:10.1246/cl.1986.1033

Reference yield: 80.0%

4-Methyl-N-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-2-(toluene-4-sulfonyl)-butyl]-benzenesulfonamide (106369-26-0) → 4-Ethyl-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrole (106369-35-1)

Guidance literature:

toluene-4-sulfonic acid; In benzene; for 0.166667h; Heating;

DOI:10.1246/cl.1986.1033

upstream raw materials:

2-Methyl-2-[2-(toluene-4-sulfonyl)-butyl]-[1,3]dioxolane

N-(p-toluenesulfonylmethyl)-p-toluenesulfonamide

toluene-4-sulfonamide

Downstream raw materials:

4-Ethyl-2-methyl-1-(toluene-4-sulfonyl)-1H-pyrrole

4-ethyl-2-methylpyrrole

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