(R)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-(2-(benzyloxy)-3-methoxyphenyl)acetate

Base Information

Chemical Name:(R)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-(2-(benzyloxy)-3-methoxyphenyl)acetate
CAS No.:1283147-55-6
Molecular Formula:C₂₃H₂₇NO₅
Molecular Weight:397.471
Hs Code.:

Synonyms:(R)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-(2-(benzyloxy)-3-methoxyphenyl)acetate

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Chemical Property of (R)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-(2-(benzyloxy)-3-methoxyphenyl)acetate

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Technology Process of (R)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-(2-(benzyloxy)-3-methoxyphenyl)acetate

There total 5 articles about (R)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-(2-(benzyloxy)-3-methoxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 122151-38-6
(S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one

: 39595-88-5
2-(2-(benzyloxy)-3-methoxyphenyl)acetic acid

: 1283147-55-6
(R)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-(2-(benzyloxy)-3-methoxyphenyl)acetate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ja2010225

Reference yield:

: 100-39-0
benzyl bromide

: 1283147-55-6
(R)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-(2-(benzyloxy)-3-methoxyphenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 50 °C / Inert atmosphere

2: sodium periodate; ruthenium trichloride; tetra-(n-butyl)ammonium iodide / ethyl acetate / 2 h / 20 °C

3: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chloride / water; acetonitrile / 4 h / 0 - 10 °C

4: triphenylphosphine; diethylazodicarboxylate / toluene / 4 h / 0 - 20 °C / Inert atmosphere

With ruthenium trichloride; sodium periodate; sodium dihydrogenphosphate; dihydrogen peroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium chloride; diethylazodicarboxylate; In water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/ja2010225

Reference yield:

: 211935-29-4
2-Benzyloxy-1-methoxy-3-(prop-2-enyl)benzene

: 1283147-55-6
(R)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-(2-(benzyloxy)-3-methoxyphenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium periodate; ruthenium trichloride; tetra-(n-butyl)ammonium iodide / ethyl acetate / 2 h / 20 °C

2: sodium dihydrogenphosphate; dihydrogen peroxide; sodium chloride / water; acetonitrile / 4 h / 0 - 10 °C

3: triphenylphosphine; diethylazodicarboxylate / toluene / 4 h / 0 - 20 °C / Inert atmosphere

With ruthenium trichloride; sodium periodate; sodium dihydrogenphosphate; dihydrogen peroxide; tetra-(n-butyl)ammonium iodide; triphenylphosphine; sodium chloride; diethylazodicarboxylate; In water; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/ja2010225