2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline

Base Information

Chemical Name:2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline
CAS No.:1159997-88-2
Molecular Formula:C₂₃H₁₇F₄N
Molecular Weight:383.388
Hs Code.:

Synonyms:2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline

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Chemical Property of 2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline

Chemical Property:

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Technology Process of 2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline

There total 3 articles about 2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159997-87-1
2-benzyl-8-fluoroisoquinolinium bromide

: 402-51-7
4-(trifluoromethyl)phenylmagnesium bromide

: 1159997-88-2
2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 17.0833h;

Reference yield:

: 1075-00-9
8-fluoroisoquinoline

: 1159997-88-2
2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 3 h / 90 °C

2: tetrahydrofuran / 17.08 h / 0 - 20 °C

In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm2013634

Reference yield:

: 100-39-0
benzyl bromide

: 1159997-88-2
2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 3 h / 90 °C

2: tetrahydrofuran / 17.08 h / 0 - 20 °C

In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm2013634