2-(adamantan-1-ylamino)-N-[3-(3-morpholin-4-yl-propoxy)-phenyl]-acetamide

Base Information

Chemical Name:2-(adamantan-1-ylamino)-N-[3-(3-morpholin-4-yl-propoxy)-phenyl]-acetamide
CAS No.:1061377-90-9
Molecular Formula:C₂₅H₃₇N₃O₃
Molecular Weight:427.587
Hs Code.:

Synonyms:2-(adamantan-1-ylamino)-N-[3-(3-morpholin-4-yl-propoxy)-phenyl]-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(adamantan-1-ylamino)-N-[3-(3-morpholin-4-yl-propoxy)-phenyl]-acetamide

Chemical Property:

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Technology Process of 2-(adamantan-1-ylamino)-N-[3-(3-morpholin-4-yl-propoxy)-phenyl]-acetamide

There total 8 articles about 2-(adamantan-1-ylamino)-N-[3-(3-morpholin-4-yl-propoxy)-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1061378-28-6
C₁₅H₂₁ClN₂O₃

: 665-66-7,13878-11-0
amantadine hydrochloride

: 1061377-90-9
2-(adamantan-1-ylamino)-N-[3-(3-morpholin-4-yl-propoxy)-phenyl]-acetamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 - 80 ℃; for 12h;

Reference yield:

: 1061378-28-6
C₁₅H₂₁ClN₂O₃

: 768-94-5
1-Adamantanamine

: 1061377-90-9
2-(adamantan-1-ylamino)-N-[3-(3-morpholin-4-yl-propoxy)-phenyl]-acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2009.01.013

Reference yield:

: 925920-62-3
3-[3-(morpholino)propoxy]benzenamine

: 1061377-90-9
2-(adamantan-1-ylamino)-N-[3-(3-morpholin-4-yl-propoxy)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C

2: N,N-dimethyl-formamide / 12 h / 20 - 80 °C

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;