(S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-oxo-1-m-tolyl-1,2-dihydroquinolin-6-yl)acetic acid

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Chemical Name:(S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-oxo-1-m-tolyl-1,2-dihydroquinolin-6-yl)acetic acid
CAS No.:1447016-66-1
Molecular Formula:C₃₄H₃₂N₂O₅
Molecular Weight:548.638
Hs Code.:

Synonyms:(S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-oxo-1-m-tolyl-1,2-dihydroquinolin-6-yl)acetic acid

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Chemical Property of (S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-oxo-1-m-tolyl-1,2-dihydroquinolin-6-yl)acetic acid

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Technology Process of (S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-oxo-1-m-tolyl-1,2-dihydroquinolin-6-yl)acetic acid

There total 15 articles about (S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-oxo-1-m-tolyl-1,2-dihydroquinolin-6-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₄N₂O₄

: 1447016-66-1
(S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-oxo-1-m-tolyl-1,2-dihydroquinolin-6-yl)acetic acid

Guidance literature:: With chromium(VI) oxide; periodic acid; In water; acetonitrile; for 2h;

Reference yield:

: 136-90-3
4-methoxy-3-methylaniline

: 1447016-66-1
(S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-oxo-1-m-tolyl-1,2-dihydroquinolin-6-yl)acetic acid

Guidance literature:: Multi-step reaction with 14 steps

1.1: sulfuric acid; 3-Nitrobenzenesulfonic acid; boric acid; ferrous(II) sulfate heptahydrate / 1 h / 140 °C

2.1: sulfuric acid; N-Bromosuccinimide / 3.5 h / 15 °C

3.1: boron tribromide / dichloromethane / 3 h

3.2: 12 h / pH 12

4.1: pyridine / dichloromethane / 2 h / -30 - 0 °C

5.1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C

6.1: AD-mix α / water; tert-butyl alcohol / 48 h / 0 °C

7.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

7.2: 2 h / 25 °C

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h

9.1: 10 h / 140 °C

10.1: methylamine / ethanol; water / 1.33 h / 78 °C

11.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 90 °C / Inert atmosphere

12.1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 22 h / 125 °C

13.1: sodium hydroxide / methanol; water; tetrahydrofuran / 24 h / 40 °C

14.1: chromium(VI) oxide; periodic acid / water; acetonitrile / 2 h

With pyridine; chromium(VI) oxide; ferrous(II) sulfate heptahydrate; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; 8-quinolinol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; AD-mix α; sulfuric acid; boric acid; boron tribromide; potassium carbonate; periodic acid; 3-chloro-benzenecarboperoxoic acid; 3-Nitrobenzenesulfonic acid; methylamine; lithium chloride; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 50741-92-9
2-methyl-4-nitroanisole

: 1447016-66-1
(S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-oxo-1-m-tolyl-1,2-dihydroquinolin-6-yl)acetic acid

Guidance literature:: Multi-step reaction with 15 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol; ethyl acetate / 24 h / 760.05 Torr

2.1: sulfuric acid; 3-Nitrobenzenesulfonic acid; boric acid; ferrous(II) sulfate heptahydrate / 1 h / 140 °C

3.1: sulfuric acid; N-Bromosuccinimide / 3.5 h / 15 °C

4.1: boron tribromide / dichloromethane / 3 h

4.2: 12 h / pH 12

5.1: pyridine / dichloromethane / 2 h / -30 - 0 °C

6.1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C

7.1: AD-mix α / water; tert-butyl alcohol / 48 h / 0 °C

8.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

8.2: 2 h / 25 °C

9.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h

10.1: 10 h / 140 °C

11.1: methylamine / ethanol; water / 1.33 h / 78 °C

12.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 90 °C / Inert atmosphere

13.1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 22 h / 125 °C

14.1: sodium hydroxide / methanol; water; tetrahydrofuran / 24 h / 40 °C

15.1: chromium(VI) oxide; periodic acid / water; acetonitrile / 2 h

With pyridine; chromium(VI) oxide; ferrous(II) sulfate heptahydrate; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; 8-quinolinol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; AD-mix α; sulfuric acid; palladium 10% on activated carbon; hydrogen; boric acid; boron tribromide; potassium carbonate; periodic acid; 3-chloro-benzenecarboperoxoic acid; 3-Nitrobenzenesulfonic acid; methylamine; lithium chloride; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;