3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester

Base Information

• Chemical Name: 3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester
• CAS No.: 960059-50-1
• Molecular Formula: C₁₈H₁₆N₂O₃S
• Molecular Weight: 340.403

Synonyms:3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester

Chemical Property of 3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester

Chemical Property:

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Technology Process of 3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester

There total 2 articles about 3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid; potassium salt (55023-72-8) + α-bromoacetophenone (70-11-1) → 3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester (960059-50-1)

Guidance literature:

In N,N-dimethyl-formamide; at 30 ℃; for 2h;

DOI:10.1080/10426500600883122

Reference yield:

ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate (52505-56-3) → 3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester (960059-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol

2: 88 percent / dimethylformamide / 2 h / 30 °C

With potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1080/10426500600883122

Reference yield: 60.0%

3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester (960059-50-1) → 8,10-dimethyl-2-phenyl-1[H]-pyrido[2',3':2,3]thieno[4,5-f][1,4]oxazepin-5-one

Guidance literature:

With PPA; at 60 - 70 ℃; for 4h;

DOI:10.1080/10426500600883122

upstream raw materials:

3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid; potassium salt

α-bromoacetophenone

ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate

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