Technology Process of C31H30FN5O5
There total 12 articles about C31H30FN5O5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride; 3-Hydroxypropionitrile;
In
tetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
With
sodium hydride; 3-hydroxylacrylic nitrile;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 12.5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 12 h / -78 - 20 °C / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Cooling with ice
3.1: sulfuric acid / acetic acid / 12 h / 0 - 20 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 - 20 °C / Inert atmosphere
4.2: 4 h / 0 - 60 °C
5.1: silver nitrate; 2,3,5-trimethyl-pyridine / dichloromethane / 12 h / 20 °C
6.1: 3-hydroxylacrylic nitrile; sodium hydride / tetrahydrofuran / 12.5 h / 0 - 20 °C
With
2,3,5-trimethyl-pyridine; dmap; sulfuric acid; sodium hydride; 3-hydroxylacrylic nitrile; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
tetrahydrofuran; dichloromethane; acetic acid; acetonitrile;