Technology Process of 4,4,8,8-tetrabutyl-2,6-bis(4-bromophenyl)pyrazabole
There total 2 articles about 4,4,8,8-tetrabutyl-2,6-bis(4-bromophenyl)pyrazabole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Na2CO3;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; water; benzene;
to soln. diiodopyrazabole in benzene Pd(PPH3)4 and satd. soln. Na2CO3 were added, warmed to 80°C, soln. 4-bromophenylboronic acid in EtOHwas added, stirred for 48 h at room temp.; org. phase was washed with water, dried over MgSO4 and evapd., column chromy. on silica (MeOH-CH2Cl2);
DOI:10.1021/ic900627g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrahydrofuran
2: Na2CO3 / tetrakis(triphenylphosphine) palladium(0) / water; ethanol; benzene
With
Na2CO3;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; water; benzene;
DOI:10.1021/ic900627g
- Guidance literature:
-
With
Pd(PAc)2; tri-o-tolylphosphine; triethylamine;
In
xylene;
(Ar) pyrazabolle, Pd(OAc)2, P(C6H4-o-Me)3 and Et3N in xylene were warmedto 60°C for 1.5 h, soln. 3,4,5-tridodecyloxystyrene in xylene wa s added and stirred at 120°C for a week; solvent was removed in vacuo, residue was dissolved in CH2Cl2 and washedwith water, solvent was evapd., column chromy. on silica (cyclohexane);
DOI:10.1021/ic900627g
