Technology Process of 4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine
There total 4 articles about 4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 40.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium; diisopropylamine / tert-butyl methyl ether; hexane / 1.67 h / -15 - -10 °C / Inert atmosphere
1.2: 0.5 h / -10 - 0 °C
2.1: 5% palladium on barium sulfate; hydrogen / tetrahydrofuran / 18 h / 20 °C / 5171.62 Torr
2.2: 1 h
3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 - 10 °C / Inert atmosphere
3.2: 20 h / 20 °C
3.3: 1 h / 20 °C
4.1: sodium hydride / mineral oil; tetrahydrofuran / 40.5 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; 5% palladium on barium sulfate; hydrogen; sodium hydride; methanesulfonyl chloride; triethylamine; diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane; tert-butyl methyl ether; mineral oil;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 - 10 °C / Inert atmosphere
1.2: 20 h / 20 °C
1.3: 1 h / 20 °C
2.1: sodium hydride / mineral oil; tetrahydrofuran / 40.5 h / 0 - 20 °C / Inert atmosphere
With
sodium hydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; dichloromethane; mineral oil;
