4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine

Base Information

Chemical Name:4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine
CAS No.:1425925-94-5
Molecular Formula:C₂₄H₂₅ClN₂O₃
Molecular Weight:424.927
Hs Code.:

Synonyms:4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine

Chemical Property:

Purity/Quality:

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Technology Process of 4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine

There total 4 articles about 4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1193-21-1
4,6-dichloropyrimidine

: 1425925-93-4
(1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentanol

: 1425925-94-5
4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 40.5h; Inert atmosphere;

Reference yield:

: 110567-22-1
(2R,3S)-benzyloxy-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexane

: 1425925-94-5
4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / tert-butyl methyl ether; hexane / 1.67 h / -15 - -10 °C / Inert atmosphere

1.2: 0.5 h / -10 - 0 °C

2.1: 5% palladium on barium sulfate; hydrogen / tetrahydrofuran / 18 h / 20 °C / 5171.62 Torr

2.2: 1 h

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 - 10 °C / Inert atmosphere

3.2: 20 h / 20 °C

3.3: 1 h / 20 °C

4.1: sodium hydride / mineral oil; tetrahydrofuran / 40.5 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; 5% palladium on barium sulfate; hydrogen; sodium hydride; methanesulfonyl chloride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; tert-butyl methyl ether; mineral oil;

Reference yield:

: 1425925-92-3
(1S,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentanol

: 1425925-94-5
4-((1R,3S,4S)-3-(benzyloxy)-4-(benzyloxymethyl)cyclopentyloxy)-6-chloropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 - 10 °C / Inert atmosphere

1.2: 20 h / 20 °C

1.3: 1 h / 20 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 40.5 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;