110567-22-1Relevant articles and documents
A New Route for the Synthesis of Entecavir
Wang, Shan-chun,Zhang, Xi-quan,Gu, Hong-mei,Zhu, Xue-yan,Guo, Ya-jun
, p. 568 - 574 (2017)
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Preparation method of entecavir intermediate
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Paragraph 0034-0036; 0040-0042; 0046-0048, (2021/06/26)
The invention provides a preparation method of an entecavir intermediate, and particularly relates to a preparation method of (1S-(1[alpha], 2[alpha], 3[beta], 5[alpha])-2-((benzyloxy) methyl)-6-oxabicyclo [3.1. 0] hexyl-3-alcohol and an oxabicyclo compound (NT02). The invention provides a brand new preparation route and reaction process conditions, and has the advantages of high operation safety, simple method, low cost and high yield. The product yield is obviously improved, and the method is very suitable for industrial production and application.
New convergent synthesis of carbocyclic nucleoside analogues
Ludek, Olaf R.,Meier, Chris
, p. 2101 - 2109 (2007/10/03)
Two convergent approaches towards the synthesis of carbocyclic nucleoside analogs will be described. Both approaches start from the stereochemically pure cyclopentenol 8 that has been prepared enantioselectively from an alkylated cyclopentadiene. Using these approaches, carbocyclic analogues of dT, FdU and BVdU have been prepared. Moreover, the conversion into the cycloSalpronucleotide and the corresponding nucleotide will be presented for one example.