phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester

Base Information

Chemical Name:phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester
CAS No.:1362039-08-4
Molecular Formula:C₄₆H₆₆N₃O₇P
Molecular Weight:804.02
Hs Code.:

Synonyms:phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester

Suppliers and Price of phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester

There total 5 articles about phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]mono[3-(hexadecyloxy)propyl]ester sodium

: 132336-30-2
(S)-N-1-[(2-hydroxy-3-triphenylmethoxy)propyl]cytosine

: 1362039-08-4
phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester

Guidance literature:: P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]mono[3-(hexadecyloxy)propyl]ester sodium; (S)-N-1-[(2-hydroxy-3-triphenylmethoxy)propyl]cytosine; With magnesium 2-methylpropan-2-olate; In N,N-dimethyl-formamide; at 77 - 83 ℃; Inert atmosphere; Industry scale;

With hydrogenchloride; In Isopropyl acetate; water; N,N-dimethyl-formamide; Product distribution / selectivity;

Reference yield:

: 129940-50-7
(S)-tritylglycidol

: 1362039-08-4
phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 85 - 95 °C / Inert atmosphere; Industry scale

1.2: 20 - 70 °C

2.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 77 - 83 °C / Inert atmosphere; Industry scale

With magnesium 2-methylpropan-2-olate; potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 36653-82-4,124-29-8
1-Hexadecanol

: 1362039-08-4
phosphonic acid [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)-2-(triphenylmethoxy)ethyl]methyl]mono[3-(hexadecyloxy)propyl]ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -5 - 30 °C / Inert atmosphere; Industry scale

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / -5 - 20 °C / Industry scale; Inert atmosphere

2.2: 20 - 55 °C / Industry scale; Inert atmosphere

3.1: pyridine / dichloromethane / -5 - 5 °C / Industry scale

3.2: 1.25 h

4.1: magnesium 2-methylpropan-2-olate / N,N-dimethyl-formamide / 77 - 83 °C / Inert atmosphere; Industry scale

With pyridine; magnesium 2-methylpropan-2-olate; sodium hydride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; mineral oil;