Technology Process of BARAC
There total 11 articles about BARAC which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
cesium fluoride;
In
acetonitrile;
for 0.75h;
DOI:10.1021/ja100014q
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / diethyl ether; hexane / 3 h / 20 °C
1.2: -78 - 20 °C
2.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / water; dichloromethane / 2.08 h / 0 - 20 °C
3.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.5 h / -78 °C
3.2: 1.5 h / -78 °C
4.1: triethylamine / dichloromethane / 26 h / 20 °C
5.1: cesium fluoride / acetonitrile / 0.75 h
With
n-butyllithium; potassium hexamethylsilazane; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; cesium fluoride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide; hydroxylamine hydrochloride / ethanol; water / 1.5 h / 20 °C / Cooling
2: hydrogenchloride; N-chloro-succinimide / N,N-dimethyl-formamide
3: triethylamine / dichloromethane / 26 h / 20 °C
4: cesium fluoride / acetonitrile / 0.75 h
With
hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; cesium fluoride; sodium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
![(Z)-5-((3-(4-(hydroxymethyl)phenyl)-4,5-dihydroisoxazol-5-yl)methyl)-6-oxo-11-(trimethylsilyl)-5,6-dihydrodibenzo[b,f]azocin-12-yl trifluoromethanesulfonate](/Databaselist/images/loading.webp)
