2-(2-chlorophenoxy)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

Base Information

Chemical Name:2-(2-chlorophenoxy)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one
CAS No.:1390656-09-3
Molecular Formula:C₂₄H₂₃ClN₆O₃
Molecular Weight:478.938
Hs Code.:

Synonyms:2-(2-chlorophenoxy)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

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Chemical Property of 2-(2-chlorophenoxy)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

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Technology Process of 2-(2-chlorophenoxy)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

There total 11 articles about 2-(2-chlorophenoxy)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390657-72-3
tert-butyl 4-(4-((2-(2-chlorophenoxy)-5-oxo-5,6-dihydropyrido[2,3-d]pyridazin-4-yl)amino)-3-methoxyphenyl)piperazine-1-carboxylate

: 1390656-09-3
2-(2-chlorophenoxy)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1390656-09-3
2-(2-chlorophenoxy)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2: hydrogen / Raney nickel / methanol / 5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 120 °C / Sealed tube

4: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere; Sealed tube

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogen; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper(l) iodide; dimethylaminoacetic acid; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 686279-09-4
ethyl 4,6-dichloro-2-methylpyridine-3-carboxylate

: 1390656-09-3
2-(2-chlorophenoxy)-4-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyridazin-5(6H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 24 h / 85 °C

2: N-methylpiperidine-N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

3: 1,4-dioxane / 15 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 120 °C / Sealed tube

6: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere; Sealed tube

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With N-methylpiperidine-N-oxide; N-Bromosuccinimide; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dibenzoyl peroxide; copper(l) iodide; dimethylaminoacetic acid; In 1,4-dioxane; tetrachloromethane; dichloromethane; acetonitrile;