(S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol

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Chemical Name:(S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol
CAS No.:552890-63-8
Molecular Formula:C₃₁H₅₄O₆S₂Si
Molecular Weight:614.984
Hs Code.:

(S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol

Synonyms:(S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol

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Chemical Property of (S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol

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Technology Process of (S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol

There total 4 articles about (S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 80910-01-6,108836-41-5,134733-19-0,144069-33-0
(S)-2-[(4-methoxybenzyloxy)methyl]oxirane

: 552890-44-5
tert-Butyl-[(4R,5S)-5-((1S,2S)-2-[1,3]dithian-2-yl-1-methyl-propyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-dimethyl-silane

: 552890-63-8
(S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol

Guidance literature:: In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1055/s-2003-37533

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 552890-63-8
(S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; DMAP / CH₂Cl₂ / 4 h / 20 °C

2: 15.7 g / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 120 h / 20 °C

3: 96 percent / t-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide; pentane / -78 - -45 °C

With dmap; tert.-butyl lithium; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; pentane;
DOI:10.1016/S0040-4020(03)00873-1

Reference yield:

: (2R,3S,4S,5S)-5-[1,3]Dithian-2-yl-4-methyl-hexane-1,2,3-triol

: 552890-63-8
(S)-1-(2-{(1S,2S)-2-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-propyl}-[1,3]dithian-2-yl)-3-(4-methoxy-benzyloxy)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; DMAP / CH₂Cl₂ / 4 h / 20 °C

2: 15.7 g / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 120 h / 20 °C

3: 96 percent / t-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide; pentane / -78 - -45 °C

With dmap; tert.-butyl lithium; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; pentane;
DOI:10.1016/S0040-4020(03)00873-1