4-NITRO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-NITRO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER
• CAS No.: 72922-61-3
• Molecular Formula: C₉H₇N₃O₄
• Molecular Weight: 221.172
• Hs Code.: 2933990090
• Mol file: 72922-61-3.mol

Synonyms:Methyl4-nitro-1H-indazole-6-carboxylate

Chemical Property of 4-NITRO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 4.72E-08mmHg at 25°C
• Refractive Index: 1.683
• Boiling Point: 443.2°C at 760 mmHg
• Flash Point: 221.8°C
• PSA: 100.80000
• Density: 1.527
• LogP: 1.78090
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Methyl4-nitro-1H-indazole-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-NITRO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

There total 5 articles about 4-NITRO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.8%

methanol (67-56-1) + C8H5N3O4 → Methyl-4-nitro-1H-indazol-6-carboxylat (72922-61-3)

Guidance literature:

With thionyl chloride; at 0 - 40 ℃; for 1h;

Reference yield: 22.0%

methyl 3-amino-4-methyl-5-nitrobenzoate (72922-60-2) → Methyl-4-nitro-1H-indazol-6-carboxylat (72922-61-3)

Guidance literature:

methyl 3-amino-4-methyl-5-nitrobenzoate; With hydrogenchloride; sodium nitrite; In water; at 0 - 20 ℃; for 1.5h;

With sulfuric acid; urea; In water; at 50 ℃; for 0.25h;

Reference yield:

3,5-dinitro-p-toluic acid (16533-71-4) → Methyl-4-nitro-1H-indazol-6-carboxylat (72922-61-3)

Guidance literature:

Multi-step reaction with 3 steps

1: water; sodium dithionite / methanol / 3 h / 60 °C

2: acetic acid; sodium nitrite / 0.33 h / 20 °C / Cooling with ice

3: thionyl chloride / 1 h / 0 - 40 °C

With thionyl chloride; sodium dithionite; water; acetic acid; sodium nitrite; In methanol;

upstream raw materials:

methyl 3-amino-4-methyl-5-nitrobenzoate

3-amino-4-methyl-5-nitrobenzoic acid

methanol

3,5-dinitro-p-toluic acid

Downstream raw materials:

C₉H₉N₃O₂

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