3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide

Base Information

• Chemical Name: 3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide
• CAS No.: 1154427-35-6
• Molecular Formula: C₁₂H₁₆BrNO₂
• Molecular Weight: 286.169
• Mol file: 1154427-35-6.mol

Synonyms:3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide

Chemical Property of 3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide

There total 1 articles about 3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

3-bromo-4-methylbenzoyl chloride (21900-33-4) + 2-Amino-2-methyl-1-propanol (124-68-5) → 3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide (1154427-35-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/acs.jmedchem.1c01403

Reference yield: 90.0%

3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide (1154427-35-6) → 2-(3-bromo-4-methylphenyl)-4,4-dimethyl-4,5-dihydrooxazole (1154427-37-8)

Guidance literature:

3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide; With thionyl chloride; at 20 ℃; for 0.333333h;

With sodium carbonate; In water; pH=9;

Reference yield:

3-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-4-methylbenzamide (1154427-35-6) → 4,4-dimethyl-2-(4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4,5-dihydrooxazole (1373940-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 12 h

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; potassium acetate; In 1,4-dioxane;

DOI:10.1021/acs.jmedchem.1c01403

upstream raw materials:

3-bromo-4-methylbenzoyl chloride

2-Amino-2-methyl-1-propanol

Downstream raw materials:

2-(3-bromo-4-methylphenyl)-4,4-dimethyl-4,5-dihydrooxazole

4,4-dimethyl-2-(4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4,5-dihydrooxazole

N-(5-(5-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-2-methylphenyl)-pyrazin-2-yl)-2,6-difluorobenzamide