6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine

Base Information

Chemical Name:6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine
CAS No.:865434-80-6
Molecular Formula:C₂₈H₂₈N₄O₈S
Molecular Weight:580.618
Hs Code.:

Synonyms:6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine

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Chemical Property of 6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine

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Technology Process of 6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine

There total 3 articles about 6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 773133-85-0
6-(hydroxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluolyl)-β-D-erythro-pentofuranosyl)purine

: 7143-01-3
Methanesulfonic anhydride

: 865434-80-6
6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 2h;
DOI:10.1039/b508122j

Reference yield:

: 773133-86-1
6-(acetyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluolyl)-β-D-erythro-pentofuranosyl)purine

: 865434-80-6
6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / aq. NH₃; ZnCl₂ / ethanol / 20 °C

2: 95 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h

With dmap; ammonium hydroxide; triethylamine; zinc(II) chloride; In ethanol; dichloromethane;
DOI:10.1039/b508122j

Reference yield:

: 91713-46-1
6-Chloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)purine

: 865434-80-6
6-(methanesulfonyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Zn; CH₂Br₂; Me₃SiCl / tetrahydrofuran / 1 h / 0 - 5 °C

1.2: 77 percent / Pd(PPh₃)4 / tetrahydrofuran / 8 h / 20 °C

2.1: 69 percent / aq. NH₃; ZnCl₂ / ethanol / 20 °C

3.1: 95 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h

With dmap; ammonium hydroxide; chloro-trimethyl-silane; triethylamine; zinc(II) chloride; zinc; 1,1-dibromomethane; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1039/b508122j