trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol

Base Information

Chemical Name:trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol
CAS No.:125974-15-4
Molecular Formula:C₂₀H₃₄O₂Si
Molecular Weight:334.574
Hs Code.:

Synonyms:trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol

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Chemical Property of trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol

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Technology Process of trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol

There total 4 articles about trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 125974-14-3
trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopentenyl Benzoate

: 125974-15-4
trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 0.5h;
DOI:10.1021/jo00296a076

Reference yield:

: 7129-41-1
6-oxabicyclo[3.1.0]hex-2-ene

: 125974-15-4
trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 1.28 M n-BuLi / 1) hexane, 0 deg C, 15 min, 2) rt

2: 88 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature

3: 92 percent / LiAlH₄ / diethyl ether / 0.5 h / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00296a076

Reference yield:

: 91098-88-3
(3S)-3-(tert-butyldimethyl-siloxy)-3-cyclohexylprop-1-yne

: 125974-15-4
trans-4-(3-((tert-Butyldimethylsilyl)oxy)-3-cyclohexyl-1-propynyl)-2-cyclopenten-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 1.28 M n-BuLi / 1) hexane, 0 deg C, 15 min, 2) rt

2: 88 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature

3: 92 percent / LiAlH₄ / diethyl ether / 0.5 h / 0 °C

With lithium aluminium tetrahydride; n-butyllithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00296a076