4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 544694-79-3
• Molecular Formula: C₃₀H₃₈N₄O₇S₂
• Molecular Weight: 630.786

Synonyms:4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

There total 12 articles about 4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-{ethoxycarbonylmethanesulfonyl-[5-(N-hydroxycarbamimidoyl)-benzo[b]thiophen-2-ylmethyl]-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester → 4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester (544694-79-3)

Guidance literature:

4-(4-{ethoxycarbonylmethanesulfonyl-[5-(N-hydroxycarbamimidoyl)-benzo[b]thiophen-2-ylmethyl]-amino}-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester; With acetic anhydride; acetic acid;

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;

DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester (544694-79-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran

2.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

3.1: NaBH(OAc)3; AcOH / CH₂Cl₂

4.1: pyridine

5.1: NH₂OH / ethanol

6.1: acetic anhydride; acetic acid

6.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester (544694-79-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran

2.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

3.1: NaBH(OAc)3; AcOH / CH₂Cl₂

4.1: pyridine

5.1: NH₂OH / ethanol

6.1: acetic anhydride; acetic acid

6.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/S0960-894X(02)00927-7

upstream raw materials:

4-fluorobenzonitrile

2-Formylbenzothiophen-5-carbonitril

2-(hydroxymethyl)benzo[b]thiophene-5-carbonitrile

4-fluoro-3-formylbenzonitrile

Downstream raw materials:

((5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-{4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-phenyl}-sulfamoyl)-acetic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 544694-79-3 4-{4-[(5-carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send