Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate

Base Information

Chemical Name:Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate
CAS No.:928783-01-1
Molecular Formula:C₂₄H₁₇Cl₂F₃N₄O₄
Molecular Weight:553.325
Hs Code.:

Synonyms:Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate

Suppliers and Price of Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate

There total 8 articles about Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 928783-01-1
Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

3.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

3.2: 1.5 h / 80 °C

4.1: ammonia / tetrahydrofuran; water / 18 h / 0 °C

5.1: potassium phosphate; N,N-dimethylethylenediamine / copper(l) iodide / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

6.1: triethylamine / dmap / tetrahydrofuran / 16 h / 20 °C

With potassium phosphate; ammonia; sodium acetate; potassium carbonate; potassium hydrogencarbonate; N,N-dimethylethylenediamine; triethylamine; dmap; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 928783-00-0
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(5-pyrimidinyl) benzoic acid amide

: 79-22-1
methyl chloroformate

: 928783-01-1
Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate

Guidance literature:: With triethylamine; dmap; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 928783-01-1
Methyl N-[4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methylbenzoyl]-N-(5-pyrimidinyl) carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

2.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

2.2: 1.5 h / 80 °C

3.1: ammonia / tetrahydrofuran; water / 18 h / 0 °C

4.1: potassium phosphate; N,N-dimethylethylenediamine / copper(l) iodide / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

5.1: triethylamine / dmap / tetrahydrofuran / 16 h / 20 °C

With potassium phosphate; ammonia; sodium acetate; potassium hydrogencarbonate; N,N-dimethylethylenediamine; triethylamine; dmap; palladium diacetate; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;