N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine benzyl ester

Base Information

Chemical Name:N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine benzyl ester
CAS No.:129432-10-6
Molecular Formula:C₄₂H₅₇N₅O₁₆
Molecular Weight:887.938
Hs Code.:

Synonyms:N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine benzyl ester

There total 7 articles about N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 100929-06-4
(S)-2-Amino-3-((2S,3R,4R,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-3-acetylamino-tetrahydro-pyran-2-yloxy)-propionic acid benzyl ester

: N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucine trifluoroacetate

: 129432-10-6
N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine benzyl ester

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In dichloromethane; for 72h;
DOI:10.1016/0008-6215(90)84081-5

Reference yield:

: 118358-66-0,73724-46-6
N-(9-fluorenylmethyloxycarbonyl)-L-serine benzyl ester

: 129432-10-6
N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1. Ag₂CO₃, Drierite, molecular sieves (3 Angstroem) 2. AgClO₄ / 1. CH₂Cl₂,toluene, -5 deg C, 30 min 2. 20 h, room temperature

2: 1. NaBH₄ 2. pyridine / 1. NiCl₂*6H₂O, boric acid / 1. EtOH 2. 2 h

3: morpholine / 0.5 h / Ambient temperature

4: 80 percent / ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate, NEt₃ / CH₂Cl₂ / 72 h

With morpholine; pyridine; calcium sulfate; sodium tetrahydroborate; 3 A molecular sieve; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; silver carbonate; boric acid; nickel dichloride; In dichloromethane;
DOI:10.1016/0008-6215(90)84081-5

Reference yield:

: 100929-00-8
benzyl O-(3,4,6-tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serinate

: 129432-10-6
N-<2-(4-pyridyl)ethoxycarbonyl>-L-threonyl-L-isoleucyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-serine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1. NaBH₄ 2. pyridine / 1. NiCl₂*6H₂O, boric acid / 1. EtOH 2. 2 h

2: morpholine / 0.5 h / Ambient temperature

3: 80 percent / ethyl 2-ethoxy-1,2-dihydroquinoline-1-carboxylate, NEt₃ / CH₂Cl₂ / 72 h

With morpholine; pyridine; sodium tetrahydroborate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; boric acid; nickel dichloride; In dichloromethane;
DOI:10.1016/0008-6215(90)84081-5