Technology Process of C19H16O3
There total 4 articles about C19H16O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bromine; acetic acid / 36 h / 25 °C / Inert atmosphere
2.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 25 °C / Inert atmosphere
3.1: trifluoroacetic acid; water / 1.5 h / 25 °C / Inert atmosphere
4.1: sodium acetate / 1 h / 140 °C / Inert atmosphere
5.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 24 h / 25 °C / Inert atmosphere
5.2: 0 - 25 °C
With
water; hydrogen; bromine; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium chloride;
palladium 10% on activated carbon;
In
methanol; dichloromethane; acetonitrile;
2.1: Stobbe Condensation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid; water / 1.5 h / 25 °C / Inert atmosphere
2.1: sodium acetate / 1 h / 140 °C / Inert atmosphere
3.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 24 h / 25 °C / Inert atmosphere
3.2: 0 - 25 °C
With
water; hydrogen; sodium acetate; trifluoroacetic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / 25 °C / Inert atmosphere
2.1: trifluoroacetic acid; water / 1.5 h / 25 °C / Inert atmosphere
3.1: sodium acetate / 1 h / 140 °C / Inert atmosphere
4.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 24 h / 25 °C / Inert atmosphere
4.2: 0 - 25 °C
With
water; hydrogen; sodium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium chloride;
palladium 10% on activated carbon;
In
methanol; dichloromethane; acetonitrile;
1.1: Stobbe Condensation;