(2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine

Base Information

• Chemical Name: (2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine
• CAS No.: 1370339-82-4
• Molecular Formula: C₄₁H₃₈ClN₇
• Molecular Weight: 664.253
• Mol file: 1370339-82-4.mol

Synonyms:(2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine

Chemical Property of (2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine

There total 2 articles about (2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carbaldehyde o-trityloxime (1370339-81-3) → (2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine (1370339-82-4)

Guidance literature:

2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carbaldehyde o-trityloxime; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.01.043

Reference yield:

1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde oxime (1370339-80-2) → (2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine (1370339-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 3 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.ejmech.2012.01.043

Reference yield: 58.0%

(2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine (1370339-82-4) + 3-(3,4-bis-benzyloxyphenyl)-propionic acid (93559-04-7) → 3-(3,4-bis-benzyloxy-phenyl)-N-(2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-ylmethyl)propionamide (1370339-83-5)

Guidance literature:

3-(3,4-bis-benzyloxyphenyl)-propionic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 20h; Inert atmosphere;

(2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl)methylamine; In tetrahydrofuran; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.01.043

upstream raw materials:

1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde oxime

2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carbaldehyde o-trityloxime

Downstream raw materials:

3-(3,4-bis-benzyloxy-phenyl)-N-(2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-ylmethyl)propionamide

N-(2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-ylmethyl)-3-(3,4-dihydroxy-phenyl)propionamide