4-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide

Base Information

Chemical Name:4-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide
CAS No.:1351476-99-7
Molecular Formula:C₂₇H₂₉N₅O
Molecular Weight:439.56
Hs Code.:

Synonyms:4-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide

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Chemical Property of 4-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide

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Technology Process of 4-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide

There total 9 articles about 4-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₃N₅O₃S

: 1351476-99-7
4-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide

Guidance literature:: C₃₃H₃₃N₅O₃S; With sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; for 2h; Reflux;

With sodium hydroxide; In methanol; for 2h; Reflux;

Reference yield:

: 1351478-03-9
3-iodo-2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 123088-59-5
4-carbamoylphenylboronic acid

: 1351476-99-7
4-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide

Guidance literature:: 3-iodo-2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 4-carbamoylphenylboronic acid; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In acetonitrile; at 60 ℃; for 2h;

With sodium hydroxide; In methanol; for 2h; Reflux;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1351476-99-7
4-(2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 2 h / 0 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -35 °C

2.2: 2 h / -35 - 20 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.08 h / 150 °C / Microwave irradiation

4.1: sodium hydroxide / methanol / 17 h / 20 °C / Reflux

5.1: N-iodo-succinimide / acetone / 1 h / 20 °C

6.1: dmap; triethylamine / dichloromethane / 48 h

7.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 2 h / 60 °C

8.1: sodium hydroxide / bis-triphenylphosphine-palladium(II) chloride / methanol / 2 h / Reflux

8.2: 2 h / Reflux

With dmap; N-iodo-succinimide; n-butyllithium; tetrabutylammomium bromide; sodium carbonate; triethylamine; diisopropylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; hexane; dichloromethane; acetone; acetonitrile; 7.1: Suzuki Coupling;