2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

Chemical Name:2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1351478-00-6
Molecular Formula:C₂₆H₂₈N₄O₂S
Molecular Weight:460.6
Hs Code.:

Synonyms:2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

There total 4 articles about 2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 763120-62-3
(4-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid

: 1111638-01-7
5-bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1351478-00-6
2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 150 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1351478-00-6
2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 2 h / 0 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -35 °C

2.2: 2 h / -35 - 20 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.08 h / 150 °C / Microwave irradiation

With n-butyllithium; tetrabutylammomium bromide; sodium carbonate; diisopropylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1351478-00-6
2-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 2 h / 0 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -35 °C

2.2: 2 h / -35 - 20 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.08 h / 150 °C / Microwave irradiation

With n-butyllithium; tetrabutylammomium bromide; sodium carbonate; diisopropylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;